Electrophoresis Market: Opportunities and challenges

CITY, Country, 2019-Nov-08 — /EPR Network/ —

The global Electrophoresis Market is expected to reach USD 2.80 Billion by 2022 from USD 2.15 Billion in 2017, at a CAGR of 5.4% during the forecast period, as per a report by MarketsandMarkets.

Why shift from plant-derived to genome-based drug discovery offers an opportunity?

The plant-derived drug candidates used for disease management often belong to a chemically similar class of natural products that have almost identical biological activity and often result in a complimenting set of therapeutic limitations (side effects, contraindications, dose limits, and site of action). Furthermore, these natural products may have an unknown site of biological action that leads to unpredictable biological activity and side effects. The therapeutic limitations of plant-derived drugs can be addressed with gene-based drug candidates that have known sites of action (specific genes or proteins). Gene-based drug development and drug screening leads to the development of effective therapeutic molecules with predictable activity, known site of action, and a faster drug screening procedure.

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The advent of genetic target-based drug discovery is resulting in an increased focus on searching for new biomarkers as well as their successful use in pharmacological investigations and pharmaceutical applications. Pertaining to this shifting trend in product development, several active clinical trials across the globe are currently utilizing gel electrophoresis systems. This trend is expected to directly result in an increase in demand for electrophoresis techniques, globally.

How safety concern associated with electrophoresis reagents remains a challenge?

Ethidium Bromide (EtBr) is the most widely used nucleic acid dye in electrophoresis. It is an intercalating agent primarily used for staining double-stranded DNA. However, the compound is highly toxic and a strong mutagenic, and may also be carcinogenic. The dye is harmful if swallowed or inhaled and also causes irritation to the eyes and respiratory system. Considering these risks, several other alternatives have been launched in the market, including SYBR dyes (SYBR Safe, SYBR Green, SYBR Gold) by Thermo Fisher Scientific (U.S.), GelRed & GelGreen by Biotium (U.S.), and GelStar by Lonza Group (Switzerland). Even though these dyes are claimed to be comparatively safer than EtBr, they are also mutagenic. These alternative dyes have higher sensitivity, and thus a very low quantity of the dye is required during the electrophoresis procedure. However, the high cost of these alternative dyes is limiting their use among researchers. Also, the familiarity with EtBr for most researchers is acting as a major hindrance for the higher acceptance of these alternative dyes. Thus, several market players are currently focusing on developing safer, highly sensitive, and low-priced nucleic acid dyes.

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