Articles by sunnyfang1419

Optimization of Three Elements of ADC Drugs

2023-07-03 // 0 Comments

Watertown, MA, 2023-Jul-03 — /EPR Network/ —Structurally, an ADC consists of monoclonal antibodies (Antibody) that target specific antigens on tumor surfaces, cytotoxic drugs (drugs) that kill tumor cells, and linkers (Conjugate/ linkers) that conjugate cytotoxic drugs to antibodies. The link between the antibody and linker is controlled by the coupling method, which determines the DAR value of the drug and affects the stability and PK characteristics of the ADC. The connection of Linker to the drug is controlled by a shearable/non-shearable technique that determines the properties of the active payload, the rate at which the payload is released, and affects the solubility, stability, and titer of the ADC.   Optimization of Antibody: Development of new targets and dual antibody ADCs   The selection of antibodies [read full press release…]

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