Hepatorenal Syndrome Therapeutics Pipeline Analysis 2018

CITY, Country, 2019-Jul-26 — /EPR Network/ —

Hepatorenal syndrome (HRS) is a reversible functional renal impairment, that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure. It is characterized by a marked reduction in glomerular filtration rate and renal plasma flow, in the absence of other causes of renal failure.

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The symptoms of hepatorenal syndrome are fatigue, abdominal pain, malaise, ascites, jaundice, splenomegaly, and hepatomegaly. There are two sub-types of this disease; type 1 and type 2 hepatorenal syndrome.

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Type 1 hepatorenal syndrome is a rapidly progressive renal failure, defined by doubling of initial serum creatinine to a level >2.5 mg/dl or by a 50% reduction in creatinine clearance to a level <20 ml/min in <2 wk. Type 2 hepatorenal syndrome is a moderate, steady renal failure with a serum creatinine of >1.5 mg/dl. Hepatoren (ifetroban) is the Phase 2 of development by Cumberland Pharmaceuticals for treating HRS. Other than this Noorik Biopharmaceuticals Ltd. is also involved in HRS pipeline.

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  • The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with the detailed analysis of pipeline and clinical trials.
  • Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licensing, grants, technology, and others.

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